International Society for the Development of Research on Magnesium

updated December 2017

Scientific Committee


Prof. Federica I. Wolf

Rome (Italy)

"Dear Colleagues and Friends,...


Past Presidents

Dr. Jean Durlach

Paris (France)


Dr. André Mazur

Clermont-Ferrand (France)

Dr. Yves Rayssiguier

Clermont-Ferrand (France)

Society Board

Andrea Fleig

Honolulu (USA)

Maria-José Laires

Lisbon (Portugal)

Michael Lenardo

Bethesda (USA)

André Mazur

Clermont-Ferrand (France)


Yves Rayssiguier

Clermont-Ferrand (France)

Edmond Rock

Clermont-Ferrand (France)


HOME | Highlights


Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes.

Qiao Y, Mondal K, Trapani V, et al. (Hum Mutat.2014 Jan;35(1):58-62)


P2X4 receptor regulation of transient receptor potential melastatin type 6 (TRPM6) Mg(2+) channels.

de Baaij JH, Blanchard MG, Lavrijsen M, et al. (Pflugers Arch. 2014 Jan 12)


Magnesium and embryonic development.

Komiya Y, Su LT, Chen HC, et al. (Magnes Res. 2014 Jan-Mar;27(1):1-8.)


Elucidation of the distal convoluted tubule transcriptome identifies new candidate genes involved in renal Mg2+ handling.

de Baaij JH, Groot Koerkamp MJ, et al. (Am J Physiol Renal Physiol. 2013 Dec;305(11):F1563-73. doi: 10.1152/ajprenal.00322.2013.)


Dietary magnesium and genetic interactions in diabetes and related risk factors: a brief overview of current knowledge.

Hruby A, McKeown NM, Song Y, Djoussé L. (Nutrients. 2013 Dec 6;5(12):4990-5011. doi: 10.3390/nu5124990.)


Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis.

Verena Schick, Jonas A Scheiber, Frank C Mooren (Gut 2013 Nov 25. doi: 10.1136/gutjnl-2012-304274. Epub ahead of print)


Magnesium Intake Is Inversely Associated With Coronary Artery Calcification: The Framingham Heart Study.

Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. (JACC Cardiovasc Imaging. 2013 Nov 20. doi: 10.1016/j.jcmg.2013.10.006. Epub ahead of print)


Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain.

Guilbert A, Gautier M, Dhennin-Duthille I,et al. (Eur J Cancer. 2013 Nov;49(17):3694-707. doi: 10.1016/j.ejca.2013.07.008.)


Importance of Metal Hydration on the Selectivity of Mg(2+) versus Ca(2+) in Magnesium Ion Channels.

Dudev T, Lim C. (J Am Chem Soc. 2013 Nov 13;135(45):17200-8. doi: 10.1021/ja4087769. Epub 2013 Oct 30.)


TRPM7 triggers Ca2+sparks and invadosome formation inneuroblastoma cells.

Daan Visser, Michiel Langeslagb, Katarzyna M. et al. (Cell Calcium 2013)


Mutations in PCBD1 Cause Hypomagnesemia and Renal Magnesium Wasting.

Ferrč S, de Baaij JH, Ferreira P, et al. (J Am Soc Nephrol. 2013 Nov 7. Epub ahead of print.)


Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its a-kinase domain.

Yogi A, Callera GE, O'Connor S, Antunes TT, Valinsky W, Miquel P, Montezano AC, Perraud AL, Schmitz C, Shrier A, Touyz RM. (Cell Signal. 2013 Nov;25(11):2163-75. Epub 2013 Jul 6.)


Magnesium deficit ? overlooked cause of low vitamin D status?

Zittermann A. (BMC Med. 2013 Oct 24;11:229. doi: 10.1186/1741-7015-11-229.)


Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus.

Wang S, Hou X, Liu Y, Lu H, Wei L, Bao Y, Jia W. (Cardiovasc Diabetol. 2013 Oct 10;12(1):146. doi: 10.1186/1475-2840-12-146.)


Magnesium-deficient high-fat diet: Effects on adiposity, lipid profile and insulin sensitivity in growing rats.

Sales CH, Santos AR, Cintra DE, Colli C. (Clin Nutr. 2013 Oct 16 doi: 10.1016/j.clnu.2013.10.004. Epub ahead of print.)


Higher magnesium intake reduces risk of impaired glucose and insulin metabolism, and progression from prediabetes to diabetes in middle-aged Americans.

Hruby A, Meigs JB, O'Donnell CJ, et al. (Diabetes Care. 2013 Oct 2. Epub ahead of print.)


Magnesium homeostasis in cardiac myocytes of Mg-deficient rats.

Tashiro M, Inoue H, Konishi M. (PLoS One. 2013 Sep 9;8(9):e73171. doi: 10.1371/journal.pone.0073171.)


The structure and regulation of magnesium selective ion channels.

Payandeh J, Pfoh R, Pai EF. (Biochim Biophys Acta. 2013 Nov;1828(11):2778-2792. Epub 2013 Aug 15.)


Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III.

Deng X, Song Y, Manson JE et al. (BMC Med. 2013 Aug 27;11(1):187. Epub ahead of print)


Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate.

Su NY, Peng TC, Tsai PS, Huang CJ. (J Surg Res. 2013 Jul 4. doi:pii: S0022-4804(13)00660-4. 10.1016/j.jss.2013.06.030. Epub ahead of print)


Substitution p.A350V in Na(+)/Mg(2+) Exchanger SLC41A1, Potentially Associated with Parkinson's Disease, Is a Gain-of-Function Mutation.

Kolisek M, Sponder G, Mastrototaro L, et al. (PLoS One. 2013 Aug 15;8(8):e71096)


SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women.

Kolisek M, Galaviz-Hernández C, Vázquez-Alaniz F, et al. (Hypertens Pregnancy. 2013 Nov;32(4):378-89)


Clinical relevance and utility of cetuximab-related changes in magnesium and calcium serum levels.

Stintzing S, Fischhaber D, Mook C, et al. (Anticancer Drugs. 2013 Oct;24(9):969-74)


TRPM7 is required for breast tumor cell metastasis.

Middelbeek J, Kuipers AJ, Henneman L, et al. (Cancer Res. 2012 Aug 15;72(16):4250-61. Epub 2012 Aug 7.)


Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.

Chaigne-Delalande B, Li FY, O'Connor GM, et al. (Science. 2013 Jul 12;341(6142):186-91)


TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway.

Meng X, Cai C, Wu J, et al. (Cancer Lett. 2013 Jun 1;333(1):96-102. doi: 10.1016/j.canlet.2013.01.031. Epub 2013 Jan 23.)


Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent.

Davis FM, Azimi I, Faville RA, Peters AA et al. (Oncogene. 2013 May 20. doi: 10.1038/onc.2013.187.)


Magnesium homeostasis and hypomagnesemia in children with malignancy.

Kaplinsky C, Alon US. (Pediatr Blood Cancer. 2013 May;60(5):734-40)


Association of hypomagnesemia with inferior survival in a phase III, randomized study of cetuximab plus best supportive care versus best supportive care alone: NCIC CTG/AGITG CO.17.

Vickers MM, Karapetis CS, Tu D, et al. (Ann Oncol. 2013 Apr;24(4):953-60)


Nature of SLC41A1 complexes: report on the split-ubiquitin yeast two hybrid assay.

Nestler A, Sponder G, Rutschmann K et al. (Magnes Res. 2013 Apr-Jun;26(2):56-66)


The SLC41 family of MgtE-like magnesium transporters.

Sahni J, Scharenberg AM. (PLoS One. 2013 Apr;34(2-3):620-8.)


Baseline serum magnesium concentrations and neurodevelopmental outcomes of extremely low birth weight premature infants.

Kim SY, El-Dib M, Ahmad T, Aly H. (Early Hum Dev. 2013 Apr;89(4):239-42.)


Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies.

Hruby A, Ngwa JS, Renström F, et al. (J Nutr. 2013 Mar;143(3):345-53.)


Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.

Qin X, Yue Z, Sun B, et al. (Br J Pharmacol. 2013 Mar;168(6):1294-312.)


Magnesium sulphate for women at term for neuroprotection of the fetus.

Nguyen TM, Crowther CA, Wilkinson D, Bain E. (Cochrane Database Syst Rev. 2013 Feb 28.)


Magnesium Supplementation Reduces Postoperative Arrhythmias After Cardiopulmonary Bypass in Pediatrics: A Metaanalysis of Randomized Controlled Trials.

Lee HY, Ghimire S, Kim EY. (Pediatr Cardiol. 2013 Feb 27.)


Safety and efficacy of calcium and magnesium infusions in the chemoprevention of oxaliplatin induced sensory neuropathy in digestive tract cancers: A meta-analysis.

Xu XT, Dai ZH, Xu Q, et al. (J Dig Dis. 2013 Feb 21.)


Modifying effect of calcium/magnesium intake ratio and mortality: a population-based cohort study.

Dai Q, Shu XO, Deng X, et al (BMJ Open. 2013 Feb 20;3(2))


The TRPM6/EGF Pathway Is Downregulated in a Rat Model of Cisplatin Nephrotoxicity.

Ledeganck KJ, Boulet GA, Bogers JJ, et al (PLoS One 2013;8(2) Epub 2013 Feb 15.)


Associations of serum and urinary magnesium with the pre-diabetes, diabetes and diabetic complications in the chinese northeast population.

Xu J, Xu W, Yao H, et al. (PLoS One 2013;8(2), Epub 2013 Feb 13.)


TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway.

Meng X, Cai C, Wu J, et al (Cancer Lett. 2013 Jan 23. Epub ahead of print)


Increase in serum Ca2+/Mg2+ ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels.

Sun Y, Selvaraj S, Varma A et al (J Biol Chem. 2013 Jan 4;288(1):255-63.)


Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells.

Louvet L, Büchel J, Steppan S et al. (Nephrol Dial Transplant. 2012 Dec 9. Epub ahead of print)


Evaluation of Hypomagnesemia: Lessons From Disorders of Tubular Transport.

Dimke H, Monnens L, Hoenderop JG, Bindels RJ. (Am J Kidney Dis. 2012 Nov 29. doi:pii: S0272-6386(12)01345-5.)


Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation.

Pfoh R, Li A, Chakrabarti N, et al (Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18809-14.)


Differential effects of cyclosporin A and tacrolimus on magnesium influx in Caco2 cells.

Gouadon E, Lecerf F, German-Fattal M. (J Pharm Pharm Sci.2012;15(3):389-98.)


The B. subtilis MgtE magnesium transporter can functionally compensate TRPM7-deficiency in vertebrate B-cells.

Sahni J, Song Y, Scharenberg AM. (Mol Aspects Med. 2012;7(9):e44452.)


Disorders of calcium and magnesium balance: a physiology-based approach.

Hoorn EJ, Zietse R. (Pediatr Nephrol. 2012 Nov 10. Epub ahead of print)


Evidence for functional expression of TRPM7 channels in human atrial myocytes.

Zhang YH, Sun HY, Chen KH, Du XL, Liu B, Cheng LC, Li X, Jin MW, Li GR. (Basic Res Cardiol. 2012 Sep;107(5):282.)


Oral magnesium lozenge reduces postoperative sore throat: a randomized, prospective, placebo-controlled study.

Borazan H, Kececioglu A, Okesli S, Otelcioglu S. (Anesthesiology. 2012 Sep;117(3):512-8.)


Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP.

Porta M, Diaz-Sylvester PL, Neumann JT, Escobar AL, Fleischer S, Copello JA. (Am J Physiol Cell Physiol. 2012 Sep 15;303(6):C682-97.)


IRBIT reduces the apparent affinity for intracellular Mg˛ in inhibition of the electrogenic Na-HCO cotransporter NBCe1-B.

Yamaguchi S, Ishikawa T. (Biochem Biophys Res Commun. 2012 Aug 3;424(3):433-8.)


Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy.

Nair AV, Hocher B, Verkaart S, van Zeeland F, Pfab T, Slowinski T, Chen YP, Schlingmann KP, Schaller A, Gallati S, Bindels RJ, Konrad M, Hoenderop JG. (Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11324-9.)


The periplasmic loop provides stability to the open state of the CorA magnesium channel.

Palombo I, Daley DO, Rapp M. (J Biol Chem. 2012 Aug 10;287(33):27547-55.)


Ion channels and transporters in lymphocyte function and immunity.

Feske S, Skolnik EY, Prakriya M. (Nat Rev Immunol. 2012 Jun 15;12(7):532-47.)


Magnesium and its transporters in cancer: a novel paradigm in tumour development.

Wolf FI, Trapani V. (Clin Sci (Lond). 2012 Oct;123(7):417-27.)


TRPM7: a unique channel involved in magnesium homeostasis.

Paravicini TM, Chubanov V, Gudermann T. (Int J Biochem Cell Biol. 2012 Aug;44(8):1381-4.)


Mg(2+) block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression.

Miyashita T, Oda Y, Horiuchi J, Yin JC, Morimoto T, Saitoe M. (Neuron. 2012 Jun 7;74(5):887-98.)


Regulation of the ATPase activity of ABCE1 from Pyrococcus abyssi by Fe-S cluster status and Mg˛: implication for ribosomal function.

Sims LM, Igarashi RY. (Arch Biochem Biophys. 2012 Aug 15;524(2):114-22.)


NMDA receptors with incomplete Mg˛ block enable low-frequency transmission through the cerebellar cortex.

Schwartz EJ, Rothman JS, Dugué GP, Diana M, Rousseau C, Silver RA, Dieudonné S. (J Neurosci. 2012 May 16;32(20):6878-93.)


Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver.

Kotani M, Kim KH, Ishizaki N, Funaba M, Matsui T. (Br J Nutr. 2012 May 9:1-8. Epub ahead of print)


Functional reconstitution and characterization of the Arabidopsis Mg(2+) transporter AtMRS2-10 in proteoliposomes.

Ishijima S, Shigemi Z, Adachi H, Makinouchi N, Sagami I. (Biochim Biophys Acta. 2012 Sep;1818(9):2202-8.)


Tungstate activates BK channels in a ß subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation.

Fernández-Marińo AI, Porras-González C, González-Rodríguez P, Selent J, Pastor M, Ureńa J, Castellano A, Valverde MA, Fernández-Fernández JM. (Cardiovasc Res. 2012 Jul 1;95(1):29-38)


Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytes.

Chokshi R, Matsushita M, Kozak JA. (Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1642-51.)


Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits.

Sharma N, Cho DH, Kim SY, Bhattarai JP, Hwang PH, Han SK. (Neurol Res. 2012 Apr;34(3):291-6.)


Differential expression of TRPM7 in rat hepatoma and embryonic and adult hepatocytes.

Lam DH, Grant CE, Hill CE. (Can J Physiol Pharmacol. 2012 Apr;90(4):435-44.)


Is ryanodine receptor a calcium or magnesium channel? Roles of K+ and Mg2+ during Ca2+ release.

Gillespie D, Chen H, Fill M. (Cell Calcium. 2012 Jun;51(6):427-33.)


Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels.

Chokshi R, Matsushita M, Kozak JA. (Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C1004-11.)


Mechanisms of Mg2+ inhibition of BzATP-dependent Ca2+ responses in THP-1 monocytes.

Jantaratnotai N, McGeer PL, McLarnon JG. (Brain Res. 2012 Mar 9;1442:1-8.)


Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations.

Nikolaev MV, Magazanik LG, Tikhonov DB. (Neuropharmacology. 2012 Apr;62(5-6):2078-85.)


Mitochondrial ATP synthase catalytic mechanism: a novel visual comparative structural approach emphasizes pivotal roles for Mg˛ and P-loop residues in making ATP.

Blum DJ, Ko YH, Pedersen PL. (Biochemistry. 2012 Feb 21;51(7):1532-46.)


Drug-induced alterations in Mg2+ homoeostasis.

Lameris AL, Monnens LA, Bindels RJ, Hoenderop JG. (Clin Sci (Lond). 2012 Jul;123(1):1-14.)


Natural and synthetic modulators of SK (K(ca) 2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7.

Chubanov V, Mederos Y Schnitzler M, Meißner M, Schäfer S, Abstiens K, Hofmann T, Gudermann T. (Br J Pharmacol. 2012 Jun;166(4):1357-76. doi: 10.1111/j.1476-5381.2012.01855.x.


Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism.

Sugimoto J, Romani AM, Valentin-Torres AM, Luciano AA, Ramirez Kitchen CM, Funderburg N, Mesiano S, Bernstein HB. (J Immunol. 2012 May 18. Epub ahead of print)


A Key Role for Mg2+ in TRPM7's Control of ROS Levels During Cell Stress.

Chen HC, Su LT, González-Pagán O, Overton JD, Runnels LW. (Biochem J. 2012 May 15. Epub ahead of print)


Magnesium sulfate reduces bacterial LPS-induced inflammation at the maternal-fetal interface.

Dowling O, Chatterjee PK, Gupta M, Tam Tam HB, Xue X, Lewis D, Rochelson B, Metz CN. (Placenta. 2012 May;33(5):392-8. Epub 2012 Feb 16.)


Hypoxia Disruption of Vertebrate CNS Pathfinding through EphrinB2 Is Rescued by Magnesium.

Stevenson TJ, Trinh T, Kogelschatz C, Fujimoto E, Lush ME, Piotrowski T, Brimley CJ, Bonkowsky JL. (PLoS Genet. 2012 Apr;8(4):e1002638. Epub 2012 Apr 12.)


Associations of dietary magnesium intake with mortality from cardiovascular disease: the JACC study.

Zhang W, Iso H, Ohira T, Date C, Tamakoshi A; JACC Study Group. (Atherosclerosis. 2012 Apr;221(2):587-95. Epub 2012 Jan 28.)


Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study.

Zhang X, Giovannucci EL, Wu K, Smith-Warner SA, Fuchs CS, Pollak M, Willett WC, Ma J (Br J Cancer. 2012 Mar 27;106(7):1335-41. doi: 10.1038/bjc.2012.76. Epub 2012 Mar 13.)


Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration.

Rybarczyk P, Gautier M, Hague F, Dhennin-Duthille I, Chatelain D, Kerr-Conte J, Pattou F, Regimbeau JM, Sevestre H, Ouadid-Ahidouch H. (Int J Cancer. 2012 Feb 10. doi: 10.1002/ijc.27487. Epub ahead of print)


Magnesium – a versatile and often overlooked element: new perspectives with a focus on chronic kidney disease.

(Clinical Kidney Journal, Volume 5 Suppl 1 February 2012)


Diabetes is the main factor accounting for hypomagnesemia in obese subjects.

Lecube A, Baena-Fustegueras JA, Fort JM, Pelegrí D, Hernández C, Simó R. (PLoS One. 2012;7(1):e30599. Epub 2012 Jan 24.)


The channel kinase, TRPM7, is required for early embryonic development.

Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. (Proc Natl Acad Sci USA. 2012 Jan 31;109(5):E225-33. Epub 2011 Dec 27.)


Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells.

Baldoli E, Maier JA. (Angiogenesis. , 2011 Dec 20. Epub ahead of print)


Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation.

Leidi M, et al. (J Nutr Biochem. , 2011 Dec 29. Epub ahead of print)


Diaza-18-crown-6 hydroxyquinoline derivatives as flexible tools for the assessment and imaging of total intracellular magnesium.

Marraccini C, et al. (Chem. Sci. , 2011, In press (DOI:10.1039/C1SC00751C)


Intracellular concentration map of magnesium in whole cells by combined use of  x-ray fluorescence microscopy and atomic force microscopy.

Lagomarsino S, et al. (Spectrochimica Acta B , 2011, In press (DOI:10.1016/j.sab.2011.11.002).


Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala.

Abumaria N et al. (J Neurosci. , 2011 Oct 19;31(42):14871-81).


The human gene SLC41A1 encodes for the Na+/Mg2+ exchanger.

Kolisek M, Nestler A, Vormann J, Schweigel-Röntgen M. (Am J Physiol Cell Physiol. , 2011 Oct 26. Epub ahead of print)


Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk between cytokines, Mg2+,NF-kB and de novo ceramide

Altura BM, Shah NC, Shah G, Zhang A, Li W, Zheng T, Perez-Albela JL, Altura BT (Am J Physiol Heart Circ Physiol., 2011 Oct 7. Epub ahead of print)


Waixenicin A inhibits cell proliferation through magnesium-dependent block of TRPM7

Zierler S, Yao G, Zhang Z, Kuo WC, Poerzgen P, Penner R, Horgen FD, Fleig A (J Biol Chem., 2011 Sep 16. Epub ahead of print)


Hydroxyapatite coating on magnesium with MgF(2) interlayer for enhanced corrosion resistance and biocompatibility

Jo JH, Kang BG, Shin KS, Kim HE, Hahn BD, Park DS, Koh YH (J Mater Sci Mater Med. 2011 Sep 10. Epub ahead of print)


Newly developed Mg-selective fluorescent probe enables visualization of Mg dynamics in mitochondria

Shindo Y, Fujii T, Komatsu H, Citterio D, Hotta K, Suzuki K, Oka K. (PLoS One., 2011;6(8):e23684. Epub 2011 Aug 16)


Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiency

Weglicki WB, Chmielinska JJ, Kramer JH, Mak IT. (Am J Med Sci., 2011 Aug;342(2):125-8)


Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

Feng-Yen Li, Benjamin Chaigne-Delalande, Chrysi Kanellopoulou, Jeremiah C. Davis, Helen F. Matthews, Daniel C. Douek, Jeffrey I. Cohen, Gulbu Uzel, Helen C. Su, Michael J. Lenardo (Nature, 475:471–476, Epub 27 July 2011)


Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia

Yogi A, Callera GE, O'Connor SE, He Y, Correa JW, Tostes RC, Mazur A, Touyz RM. (J Hypertens., 2011 Jul;29(7):1400-10)


Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells.

Ikari A, Sawada H, Sanada A, Tonegawa C, Yamazaki Y, Sugatani J. (J Cell Biochem., 2011 Jul 21. doi: 10.1002/jcb.23284. Epub ahead of print)


The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7

Deason-Towne F, Perraud AL, Schmitz C. (FEBS Lett. 2011 Jul 21;585(14):2275-8. Epub 2011 May 27)


Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro

Zhang J, Zhao F, Zhao Y, Wang J, Pei L, Sun N, Shi J. (J Biol Chem., 2011 Jun 10;286(23):20194-207. Epub 2011 Apr 12)


Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer.

Dai Q, Motley SS, Smith JA Jr, Concepcion R, Barocas D, Byerly S, Fowke JH. (PLoS One. 2011 Apr 25;6(4):e18237)


Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior

Whittle N, Li L, Chen WQ, Yang JW, Sartori SB, Lubec G, Singewald N. (Amino Acids. 2011 Apr;40(4):1231-48. Epub 2011 Feb 11)