International Society for the Development of Research on Magnesium

Scientific Committee


Prof. Federica I. Wolf

Rome (Italy)

"Dear Colleagues and Friends,...


Past Presidents

Dr. Jean Durlach

Paris (France)


Dr. André Mazur

Clermont-Ferrand (France)

Dr. Yves Rayssiguier

Clermont-Ferrand (France)

Society Board

Andrea Fleig

Honolulu (USA)

Thomas Gudermann

Munich (Germany)

Michael Lenardo

Bethesda (USA)

André Mazur

Clermont-Ferrand (France)


Yves Rayssiguier

Clermont-Ferrand (France)

Edmond Rock

Clermont-Ferrand (France)


HOME | Highlights


2011 | 2012 | 2013 | 2014 | 2015

Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice.

Ryazanova LV, Hu Z, Suzuki S, et al. (Sci Rep. 2014 Dec 23;4:7599)


TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways.

Liu M, Inoue K, Leng T, et al. ( Cell Signal. 2014 Dec;26(12):2773-81)


Down-regulation of transient receptor potential (TRP) M6 channel as a cause of hypermagnesiuric hypomagnesemia in obese type-2 diabetic rats.

Takayanagi K, Shimizu T, Tayama Y, et al. ( Am J Physiol Renal Physiol. 2014 Dec 17)


TRPM7 regulates vascular endothelial cell adhesion and tube formation.

Zeng Z, Inoue K, Sun H, et al. ( Am J Physiol Cell Physiol. 2014 Dec 3)


Segmental transport of Ca2+ and Mg2+ along the gastrointestinal tract.

Lameris AL, Nevalainen PI, Reijnen D, et al. ( Am J Physiol Gastrointest Liver Physiol. 2014 Dec 4)


RPM7 regulates proliferation and polarisation of macrophages.

Schilling T, Miralles F, Eder C. ( J Cell Sci. 2014 Nov 1;127(21):4561-6)


Identification of a Mg2+-sensitive ORF in the 5'-leader of TRPM7 magnesium channel mRNA

Nikonorova IA, Kornakov NV, Dmitriev SE, et al. (Nucleic Acids Res. 2014 Nov 10;42(20):12779-88)


Natural and Synthetic Modulators of the TRPM7 Channel.

Chubanov V, Schäfer S, Ferioli S, Gudermann T. (Cells. 2014 Nov 27;3(4):1089-1101)


TRPM7 is required for ovarian cancer cell growth, migration and invasion.

Wang J, Liao QJ, Zhang Y et al. (Biochem Biophys Res Commun. 2014 Oct 30;454(4):547-553)


EGF stimulates Mg(2+) influx in mammary epithelial cells.

Trapani V, Arduini D, Luongo F, et al. (Biochem Biophys Res Commun. 2014 Oct 30;454(4):572-575)


TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells.

Xiao E, Yang H, Gan YH, et al. (Stem Cells. 2014 Sep 29)


N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.

Zhang Z, Faouzi M, Huang J, et al. (Oncotarget. 2014 Sep 15;5(17):7625-34)


TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways.

Liu M, Inoue K, Leng T, et al. (Cell Signal. 2014 Sep 1)


TRPM7 involvement in cancer: a potential prognostic factor.

Dhennin-Duthille I, Gautier M, Korichneva I, Ouadid-Ahidouch H. (Magnes Res. 2014 Aug 1;27(3):103-12)


Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation.

Solanki MH, Chatterjee PK, Gupta M, et al. (J Physiol Renal Physiol. 2014 Aug 15;307(4):F369-84)


Expression and Contributions of TRPM7 and KCa2.3/SK3 Channels to the Increased Migration and Invasion of Microglia in Anti-Inflammatory Activation States.

Siddiqui T, Lively S, Ferreira R, et al. (PLoS One. 2014 Aug 22;9(8):e106087)


Domino effect of hypomagnesemia on the innate immunity of Crohn's disease patients.

Naser SA, Abdelsalam A, Thanigachalam et al. (World J Diabetes. 2014 Aug 15;5(4):527-35)


TGF-ß1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-ß1/Smad pathway.

Fang L, Huang C, Meng X, et al. (Toxicol Appl Pharmacol. 2014 Aug 19)


Comparing the expression patterns of placental magnesium/phosphorus-transporting channels between healthy and preeclamptic pregnancies.

Yang H, Kim TH, Lee GS, et al. (Mol Reprod Dev. 2014 Aug 22 (2.675)


Maternal Magnesium Deficiency in Mice Leads to Maternal Metabolic Dysfunction And Altered Lipid Metabolism with Fetal Growth Restriction.

Gupta M, Solanki MH, Chatterjee PK et al. (Mol Med. 2014 Jul 11)


Inhibition of TRPM7 channels reduces degranulation and release of cytokines in rat bone marrow-derived mast cells.

Huang L, Ng NM, Chen M, et al. (Int J Mol Sci. 2014 Jul 3;15(7):11817-31)


Inactivation of TRPM7 kinase activity does not impair its channel function in mice.

Kaitsuka T, Katagiri C, Beesetty P, et al. (Sci Rep. 2014 Jul 17;4:5718)


Following OGD/R, Annexin 1 Nuclear Translocation and Subsequent Induction of Apoptosis in Neurons Are Assisted by Myosin IIA in a TRPM7 Kinase-Dependent Manner.

Zhao Y, Wang J, Jiang H, et al. (Mol Neurobiol. 2014 Jun 18)


New TRPM6 mutation and management of hypomagnesaemia with secondary hypocalcaemia.

Katayama K, Povalko N, Yatsuga S, et al. (Brain Dev. 2014 Jun 28. pii: S0387-7604(14)00154-5)


Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.

van der Wijst J, Blanchard MG, Woodroof HI, et al. (Biochem J. 2014 Jun 1;460(2):165-75)


Claudins and the Kidney.

Yu AS (J Am Soc Nephrol. 2014 Jun 19)


Magnesium loss in cyclosporine-treated patients is related to renal epidermal growth factor downregulation.

Ledeganck KJ, De Winter BY, Van den Driessche A, et al. (Nephrol Dial Transplant. 2014 May;29(5):1097-102)


TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.

Brandao K, Deason-Towne F, Zhao X, et al. (Cell Mol Life Sci. 2014 May 25)


Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.

Ikari A, Tonegawa C, Sanada A, et al. (J Biol Chem. 2014 May 9;289(19):13112-23)


The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.

Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. (Cell. 2014 May 22;157(5):1061-72)


TRPM7 is involved in angiotensin II induced cardiac fibrosis development by mediating calcium and magnesium influx.

Yu Y, Chen S, Xiao C, et al. (Cell Calcium. 2014 May;55(5):252-60)


Endotoxin induces fibrosis in vascular endothelial cells through a mechanism,dependent on transient receptor protein melastatin 7 activity.

Echeverría C, Montorfano I, Hermosilla (PLoS One. 2014 Apr 7;9(4):e94146)


CNNM2 mutations cause impaired brain development and seizures in patients with hypomagnesemia.

Arjona FJ, de Baaij JH, Schlingmann KP, et al. (PLoS Genet. 2014 Apr 3;10(4):e1004267)


XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus.

Li FY, Chaigne-Delalande B, Su H, et al. (Blood. 2014 Apr 3;123(14):2148-52)


Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.

Orchard TS, Larson JC, Alghothani N, et al. (Am J Clin Nutr. 2014 Apr;99(4):926-33)


The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.

Hardy S, Uetani N, Wong N, et al. (Oncogene. 2014 Mar 17)


Activation of TRPM7 channels by small molecules under physiological conditions.

Hofmann T, Schäfer S, Linseisen M, et al. (Pflugers Arch. 2014 Mar 15)


Dietary magnesium intake and risk of cancer: a meta-analysis of epidemiologic studies.

Ko HJ, Youn CH, Kim HM, et al. (Nutr Cancer. 2014;66(6):915-23)


The channel-kinase TRPM7, revealing the untold story of Mg(2+) in cellular signaling.

Schmitz C, Brandao K, Perraud AL. (Magnes Res. 2014 Jan-Mar;27(1):9-15)


Magnesium inhibits Wnt/ß-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells.

Montes de Oca A, Guerrero , Martinez-Moreno JM, et al. (PLoS One. 2014 Feb 25;9(2):e89525)


Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.

Decker AR, McNeill MS, Lambert AM, et al. (Dev Biol. 2014 Feb 15;386(2):428-39)


The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.

Zhang Z, Yu H, Huang J, et al. (J Biol Chem. 2014 Feb 21;289(8):5217-27)


Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk.

Guasch-Ferré M, Bulló M, Estruch R (J Nutr. 2014 Jan;144(1):55-60)


Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes.

Qiao Y, Mondal K, Trapani V, et al. (Hum Mutat. 2014 Jan;35(1):58-62)


P2X4 receptor regulation of transient receptor potential melastatin type 6 (TRPM6) Mg(2+) channels.

de Baaij JH, Blanchard MG, Lavrijsen M, et al. (Pflugers Arch. 2014 Jan 12)


Magnesium and embryonic development.

Komiya Y, Su LT, Chen HC, et al. (Magnes Res. 2014 Jan-Mar;27(1):1-8.)