ARCHIVES | 2011 – 2012 – 2013 – 2014 – 2015 2011 The channel kinase, TRPM7, is required for early embryonic development Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. (Proc Natl Acad Sci USA. 2012 Jan 31;109(5):E225-33. Epub 2011 Dec 27.) Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells Baldoli E, Maier JA. (Angiogenesis. , 2011 Dec 20. Epub ahead of print) Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation Leidi M, et al. (J Nutr Biochem. , 2011 Dec 29. Epub ahead of print) Diaza-18-crown-6 hydroxyquinoline derivatives as flexible tools for the assessment and imaging of total intracellular magnesium Marraccini C, et al. (Chem. Sci., 2011, In press (DOI:10.1039/C1SC00751C) Intracellular concentration map of magnesium in whole cells by combined use of x-ray fluorescence microscopy and atomic force microscopy Lagomarsino S, et al. (Spectrochimica Acta B , 2011, In press (DOI:10.1016/j.sab.2011.11.002) Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala Abumaria N et al. (J Neurosci. , 2011 Oct 19;31(42):14871-81). The human gene SLC41A1 encodes for the Na+/Mg2+ exchanger Kolisek M, Nestler A, Vormann J, Schweigel-Röntgen M. (Am J Physiol Cell Physiol. , 2011 Oct 26. Epub ahead of print) Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk between cytokines, Mg2+,NF-kB and de novo ceramide Altura BM, Shah NC, Shah G, Zhang A, Li W, Zheng T, Perez-Albela JL, Altura BT (Am J Physiol Heart Circ Physiol., 2011 Oct 7. Epub ahead of print) Waixenicin A inhibits cell proliferation through magnesium-dependent block of TRPM7 Zierler S, Yao G, Zhang Z, Kuo WC, Poerzgen P, Penner R, Horgen FD, Fleig A (J Biol Chem., 2011 Sep 16. Epub ahead of print) Hydroxyapatite coating on magnesium with MgF(2) interlayer for enhanced corrosion resistance and biocompatibility Jo JH, Kang BG, Shin KS, Kim HE, Hahn BD, Park DS, Koh YH (J Mater Sci Mater Med. 2011 Sep 10. Epub ahead of print) Newly developed Mg-selective fluorescent probe enables visualization of Mg dynamics in mitochondria Shindo Y, Fujii T, Komatsu H, Citterio D, Hotta K, Suzuki K, Oka K. (PLoS One., 2011;6(8):e23684. Epub 2011 Aug 16) Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiency Weglicki WB, Chmielinska JJ, Kramer JH, Mak IT. (Am J Med Sci., 2011 Aug;342(2):125-8) Second messenger role for Mg2+ revealed by human T-cell immunodeficiency Feng-Yen Li, Benjamin Chaigne-Delalande, Chrysi Kanellopoulou, Jeremiah C. Davis, Helen F. Matthews, Daniel C. Douek, Jeffrey I. Cohen, Gulbu Uzel, Helen C. Su, Michael J. Lenardo (Nature, 475:471–476, Epub 27 July 2011) Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia Yogi A, Callera GE, O’Connor SE, He Y, Correa JW, Tostes RC, Mazur A, Touyz RM. (J Hypertens., 2011 Jul;29(7):1400-10) Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells Ikari A, Sawada H, Sanada A, Tonegawa C, Yamazaki Y, Sugatani J. (J Cell Biochem., 2011 Jul 21. doi: 10.1002/jcb.23284. Epub ahead of print) The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7 Deason-Towne F, Perraud AL, Schmitz C. (FEBS Lett. 2011 Jul 21;585(14):2275-8. Epub 2011 May 27) Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro Zhang J, Zhao F, Zhao Y, Wang J, Pei L, Sun N, Shi J. (J Biol Chem., 2011 Jun 10;286(23):20194-207. Epub 2011 Apr 12) Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer Dai Q, Motley SS, Smith JA Jr, Concepcion R, Barocas D, Byerly S, Fowke JH. (PLoS One. 2011 Apr 25;6(4):e18237) Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior Whittle N, Li L, Chen WQ, Yang JW, Sartori SB, Lubec G, Singewald N. (Amino Acids. 2011 Apr;40(4):1231-48. Epub 2011 Feb 11)